Mark & Associates, P.C. Attorneys At Law

Stevens Johnson Syndrome

Stevens-Johnson Syndrome is a serious medical condition commonly caused by an allergic reaction to medications. While Stevens Johnson Syndrome can be caused by many different drugs, it is commonly caused by reactions to antibiotics, anti-convulsants (seizure medications), and pain relievers. Newer generation COX II inhibitor painkillers like Bextra and Vioxx, both of which have been recalled and Celebrex have been linked to SJS. Older painkillers, many of which are available over-the-counter without a prescription, such as Motrin, Ibuprofin, Children's Motrin and Advil, are also associated with Stevens-Johnson Syndrome.

Stevens Johnson Syndrome patients suffer from inflammation of the skin and mucous membranes. Since mucous membranes are present in many organs throughout the body, such as the eyes, digestive system, lungs and respiratory system, many organs can become significantly affected during the disease process. SJS technically is an immune-complex-mediated hypersensitivity (allergic) condition. It is a severe expression of the condition known as erythema multiforme and is a lesser form of the condition known as toxic epidermal necrolysis. SJS is a serious disorder with potential for severe morbidity and in some cases, it can be fatal.

Erythema multiforme can be present and become noticeable in the form of a classic skin lesion, without displaying whole-body symptoms. This condition is normally associated with herpes simplex or mycoplasma infections. It occurs most often in children and young adults.

Stevens-Johnson Syndrome is a much more severe condition than erythema multiforme. SJS typically involves multiple areas of the body and extensive lesion formation. The lesions can extend to the mucous membranes, thus affecting the lungs, eyes, mouth, stomach, intestines and virtually every major organ.

Toxic Epidermal Necrolysis is the most severe condition associated with immune complex hypersensitivity. This condition involves multiple large blisters that coalesce, followed by a sloughing of most of the skin and mucous membranes.